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Active ingredients in Angelica sinensis extract.
2024-12-01
1. Introduction
Angelica sinensis, a well - known traditional Chinese medicinal herb, has been widely used for centuries. Its extract contains a rich variety of active ingredients, which contribute to its numerous pharmacological effects and wide applications in medicine and health care. In this article, we will explore the main active ingredients in Angelica sinensis extract in detail.
2. Z - ligustilide
Z - ligustilide is one of the most important active ingredients in Angelica sinensis. It belongs to the phthalide family. This compound has attracted significant attention due to its remarkable pharmacological properties.
2.1 Vasodilatory effects
One of the key functions of Z - ligustilide is its vasodilatory effects. By acting on the smooth muscle cells of blood vessels, it causes the blood vessels to relax and dilate. This dilation of blood vessels has several important consequences.
2.2 Improvement of blood circulation
As a result of vasodilation, the blood flow through the vessels becomes more efficient, which effectively improves blood circulation. This is beneficial for delivering oxygen and nutrients to various tissues and organs throughout the body more effectively.
2.3 Blood pressure regulation
The vasodilatory effect of Z - ligustilide also plays a role in blood pressure regulation. When blood vessels are dilated, the resistance to blood flow is reduced, which in turn leads to a decrease in blood pressure. This property makes it potentially useful in the treatment of hypertension, as it can help relieve the symptoms associated with high blood pressure.
3. Alkaloids
Angelica sinensis extract also contains alkaloids, which are another group of important active ingredients. These alkaloids have significant effects on the cardiovascular system.
3.1 Heart rate regulation
One of the ways in which alkaloids in Angelica sinensis act on the cardiovascular system is through heart rate regulation. They can interact with the heart's pacemaker cells and the autonomic nervous system to adjust the heart rate to a more appropriate level. This is crucial for maintaining normal cardiac function.
3.2 Improvement of myocardial contractility
Furthermore, these alkaloids can enhance the contractility of the heart muscle (myocardium). By increasing the force of contraction, the heart is able to pump blood more effectively, which is essential for ensuring adequate blood supply to the body.
4. Coumarins
Coumarins are also present in the Angelica sinensis extract. These compounds possess unique pharmacological properties.
4.1 Anticoagulant properties
Coumarins in Angelica sinensis have anticoagulant properties similar to warfarin, although their mechanism of action may be different. They are able to prevent the excessive coagulation of blood within the body. This anticoagulant effect is important for maintaining normal blood flow and preventing the formation of blood clots, which can lead to serious cardiovascular and cerebrovascular diseases such as thrombosis and embolism.
5. Organic acids
The organic acids in Angelica sinensis extract play a significant role in the digestive system.
5.1 Promotion of digestion and absorption
These organic acids can stimulate the secretion of digestive juices, such as gastric acid and pancreatic juice. This helps in the breakdown of food substances, thereby promoting digestion and absorption of nutrients. They also improve the motility of the gastrointestinal tract, which is essential for the proper movement of food through the digestive system.
5.2 Treatment of digestive system diseases
Due to their positive effects on the gastrointestinal function, organic acids in Angelica sinensis extract can be beneficial in the treatment of some digestive system diseases, such as indigestion, gastritis, and intestinal dysmotility. They can help relieve symptoms such as abdominal pain, bloating, and nausea.
6. Conclusion
In conclusion, the Angelica sinensis extract contains a diverse range of active ingredients, including Z - ligustilide, alkaloids, coumarins, and organic acids. Each of these components has its own unique pharmacological effects, which together contribute to the wide application of Angelica sinensis in medicine and health care. Further research on these active ingredients may lead to the development of new drugs and therapies for various diseases. However, it should also be noted that more in - depth studies are needed to fully understand the safety and efficacy of Angelica sinensis extract and its active ingredients, especially when considering its use in combination with other medications or in different patient populations.
FAQ:
What are the main active ingredients in Angelica sinensis extract?
Z - ligustilide, alkaloids, coumarins and organic acids are among the main active ingredients in Angelica sinensis extract.
How does Z - ligustilide in Angelica sinensis extract affect blood circulation?
Z - ligustilide has vasodilatory effects. By dilating blood vessels, it can improve blood circulation.
What is the role of alkaloids in Angelica sinensis extract on the cardiovascular system?
Alkaloids in Angelica sinensis extract can act on the cardiovascular system. For example, they can regulate the heart rate and improve the contractility of the heart muscle.
How do coumarins in Angelica sinensis extract prevent excessive blood coagulation?
Coumarins in Angelica sinensis extract have anticoagulant properties similar to warfarin but with a different mechanism of action, which can prevent the excessive coagulation of blood in the body.
How do the organic acids in Angelica sinensis extract help with digestive system diseases?
The organic acids in Angelica sinensis extract can promote digestion and absorption, improve the function of the gastrointestinal tract, which is helpful in the treatment of some digestive system diseases.
Related literature
- Analysis of Active Ingredients in Angelica sinensis Extract and Their Pharmacological Effects"
- "The Composition and Medicinal Value of Angelica sinensis Extract"
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