UMass Amherst Study Highlights Syrian Rue’s Potential in Treating Anxiety and Depression

Nazim Mamedov, an adjunct assistant professor at the Stockbridge School of Agriculture at the University of Massachusetts Amherst, is garnering attention for his insights into the pharmacological properties of Syrian rue (Peganum harmala). His latest research, published as chapters in "Biodiversity, Conservation and Sustainability in Asia," is set to enhance his courses on herbal medicine.

Historically known for its ritualistic and psychedelic use, Syrian rue has played a role in traditional folk medicine across Central Asia, the Middle East, and Azerbaijan, Mamedov's birthplace. Modern scientific methods and advanced laboratory equipment have enabled Mamedov to demonstrate the plant's potential in treating anxiety and depression.

In a small-scale study conducted by Mamedov, 90% of participants reported alleviation of mild to moderate symptoms of anxiety and depression. Moreover, Syrian rue is cited for its antispasmodic and analgesic effects, particularly beneficial in managing Parkinson's disease, eye ailments, and rheumatoid arthritis. Mamedov also references prior research indicating the plant's potential role in suppressing cancerous tumor growth.

An expert in ethnobotany and ethnopharmacology, with over 90 publications to his name, Mamedov recently delivered a webinar titled "Medicinal Plants for Cancer Treatment" to audiences at the University of Maragheh in Iran.

Mamedov has also directed attention to another plant native to Iran—thyme (Thymus)—noting its underexplored pharmacological properties despite its use as an expectorant for chest congestion. He has employed phytochemical analysis to spotlight the essential oils of thyme, highlighting their antibacterial, antimicrobial, and antioxidant properties. Specifically, thymol in thyme oils is effective against pathogens such as Streptococcus, Staphylococcus, E. coli, and Salmonella.

Together with student Alina Gusev, Mamedov published findings in Acta Botanica Caucasica that delve into the relationship between flower color and the healing abilities of medicinal plants. Their study suggests that purple flowering herbs bolster the immune system, blue ones possess anti-inflammatory effects, yellow herbs aid digestion, and white ones soothe or regulate the nervous system. While not definitive, such correlations provide valuable insights and serve as a scientific framework for students exploring the natural world.

Mamedov’s ongoing research underscores the vast potential of herbal medicine and invites further exploration into traditional plants for modern therapeutic applications.