By 2060, nearly 14 million Americans are projected to be living with Alzheimer’s disease, a condition that slowly erodes memory, cognitive function, independence, and personal relationships. Despite decades of research, scientists have yet to find a cure for this devastating illness. While current treatments can delay symptom progression for up to a year, they cannot halt the disease’s course.
Now, a groundbreaking class of drugs is bringing renewed hope for patients and families navigating early-stage Alzheimer’s. The Food and Drug Administration (FDA) has approved two medications—Leqembi and Kisunla—that have shown promise in slowing cognitive decline. These therapies target amyloid plaques, abnormal protein clusters that accumulate in the brain and disrupt cell communication. By clearing these plaques, the drugs can extend the time patients maintain higher levels of cognitive function and independence.
Leqembi and Kisunla mark a significant step forward in Alzheimer’s treatment, but they come with notable logistical and financial challenges. Patients seeking these drugs must navigate insurance hurdles and obtain prescriptions, all while committing to regular clinic visits for biweekly infusion sessions lasting around an hour.
These treatments also pose substantial risks, including potential brain swelling and bleeding, necessitating close medical monitoring with routine checkups and brain imaging scans. The financial burden is another significant obstacle: Kisunla, developed by Eli Lilly, carries an estimated cost of over $48,000 for an 18-month course without insurance. Meanwhile, Eisai and Biogen’s Leqembi costs approximately $26,500 annually.
Despite these challenges, many families are encouraged by the advent of these new treatment options, offering hope in the fight against an incurable disease. The development of Leqembi and Kisunla highlights progress in Alzheimer’s research—and researchers remain ambitious, as hundreds of clinical trials for new treatments are underway. Experts anticipate that the next decade could bring further medical breakthroughs.
As lifespans continue to lengthen, addressing Alzheimer’s has become increasingly urgent. Investment in brain health research, innovative drug development, and lifestyle-based interventions is critical not only to treating but ultimately preventing Alzheimer’s disease. For now, Leqembi and Kisunla affirm that science is moving closer to building a brighter future for those affected by this condition.