Grape Seed Extract: A Comprehensive Guide to Its Health Benefits

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1. Introduction to Pine Bark Extract

1. Introduction to Pine Bark Extract

Pine bark extract, also known as Pycnogenol, is a natural supplement derived from the bark of the French maritime pine tree, Pinus pinaster. This unique extract has gained significant attention in the world of health and wellness due to its wide range of potential health benefits. Pine bark has been used traditionally for centuries in various cultures for its medicinal properties, but it wasn't until the 20th century that modern research began to uncover the true extent of its health-promoting effects.

The French maritime pine tree is native to the coastal regions of southwestern France, where it thrives in the harsh, sandy soils and saline air. The bark of this tree contains a rich concentration of bioflavonoids, specifically a group known as proanthocyanidins, which are the primary active compounds in pine bark extract. These bioflavonoids are powerful antioxidants that can help protect the body against oxidative stress and inflammation, two major contributors to various chronic diseases and aging.

Pine bark extract is available in various forms, including capsules, tablets, and powders, making it easy to incorporate into a daily health regimen. It is often used as a dietary supplement to support overall health and well-being, with specific benefits for cardiovascular health, skin health, and cognitive function.

In this article, we will explore the chemical composition, antioxidant properties, and health benefits of pine bark extract, as well as compare it to another popular antioxidant supplement, Grape Seed Extract. We will also discuss usage and dosage recommendations, potential side effects, and provide a personal recommendation on which supplement may be best suited for your individual needs.

2. Chemical Composition of Grape Seed Extract

2. Chemical Composition of Grape Seed Extract

Grape Seed Extract is a popular dietary supplement that is derived from the seeds of grapes, particularly those of red wine grapes. It is known for its rich content of bioactive compounds that contribute to its health-promoting properties. The chemical composition of Grape Seed Extract is quite diverse, and it includes a variety of beneficial compounds such as:

1. Proanthocyanidins: These are a type of flavonoid that are particularly abundant in grape seeds. They are known for their strong antioxidant properties and are believed to be responsible for many of the health benefits associated with Grape Seed Extract.

2. Vitamins and Minerals: Grape Seed Extract contains a range of essential vitamins and minerals, including vitamin E, vitamin C, and trace minerals like zinc and copper. These nutrients play a crucial role in maintaining overall health and well-being.

3. Phenolic Acids: These compounds are another class of antioxidants found in Grape Seed Extract. They contribute to the overall antioxidant capacity of the extract and may also have anti-inflammatory effects.

4. Linoleic Acid: This is an essential fatty acid that is a component of grape seed oil, which is often extracted along with the Grape Seed Extract. Linoleic acid is important for maintaining healthy skin and may also have anti-inflammatory properties.

5. Resveratrol: Although present in lower concentrations in grape seeds compared to grape skins, resveratrol is a powerful antioxidant and anti-inflammatory compound that has been linked to a variety of health benefits, including cardiovascular health and anti-aging effects.

6. Tannins: These are naturally occurring compounds that can have astringent properties. They are found in grape seeds and may contribute to the overall health benefits of Grape Seed Extract.

7. Flavonoids: In addition to proanthocyanidins, Grape Seed Extract contains other flavonoids that have antioxidant and anti-inflammatory properties.

The synergistic action of these compounds is what makes Grape Seed Extract a potent source of natural antioxidants and a valuable addition to a health-conscious lifestyle. It is important to note that the exact composition of Grape Seed Extract can vary depending on the grape variety used, the extraction process, and the specific product formulation.

3. Chemical Composition of Pine Bark Extract

3. Chemical Composition of Pine Bark Extract

Pine bark extract, derived primarily from the bark of Pinus pinaster, commonly known as the maritime pine, is a rich source of natural compounds that contribute to its diverse health benefits. The chemical composition of pine bark extract is complex and includes a variety of bioactive molecules that work synergistically to support overall health and well-being. Here are some of the key components found in pine bark extract:

1. Proanthocyanidins: These are a class of bioflavonoids that are particularly abundant in pine bark. They are known for their strong antioxidant properties and are often referred to as oligomeric proanthocyanidins (OPCs) in the context of pine bark extract.

2. Catechins: Similar to proanthocyanidins, catechins are another group of flavonoids that contribute to the antioxidant capacity of pine bark extract. They are also found in green tea and have been studied for their health benefits.

3. Tannins: Tannins are a group of naturally occurring polyphenols that are known for their astringent properties. They can help to protect cells from oxidative damage and support skin health.

4. Flavonols: These are a subgroup of flavonoids that include compounds like Quercetin and kaempferol. They have been linked to a range of health benefits, including anti-inflammatory and immune-boosting properties.

5. Phenolic Acids: Phenolic acids, such as ferulic acid and vanillic acid, are present in pine bark extract and contribute to its antioxidant and anti-inflammatory effects.

6. Carotenoids: Although not as abundant as in some other plant sources, carotenoids like lutein and zeaxanthin are also found in pine bark extract and are important for eye health.

7. Vitamins and Minerals: Pine bark extract contains trace amounts of vitamins and minerals that support overall health, including vitamin C and various trace minerals.

8. Polysaccharides: These are complex carbohydrates that can have immune-modulating effects and contribute to the overall health-promoting properties of pine bark extract.

The synergistic action of these compounds is believed to be responsible for the wide range of health benefits associated with pine bark extract. As research continues, the specific mechanisms by which these components interact and contribute to health are becoming clearer, highlighting the potential of pine bark extract as a natural health supplement.

4. Antioxidant Properties of Grape Seed Extract

4. Antioxidant Properties of Grape Seed Extract

Grape Seed Extract is renowned for its potent antioxidant properties, which are primarily attributed to its high content of oligomeric proanthocyanidins (OPCs), a type of flavonoid. These compounds are particularly effective at neutralizing free radicals, which are unstable molecules that can cause damage to cells and contribute to the aging process and various diseases.

Mechanism of Antioxidant Action
The antioxidant mechanism of Grape Seed Extract involves several pathways:

1. Scavenging Free Radicals: OPCs in Grape Seed Extract can donate electrons to free radicals, thereby stabilizing them and preventing them from causing oxidative damage to cellular components such as DNA, proteins, and lipids.

2. Metal Chelation: Grape Seed Extract can bind to metal ions, such as iron and copper, which are known to catalyze the formation of free radicals. By chelating these metals, Grape Seed Extract reduces their ability to participate in oxidative reactions.

3. Enhancing Endogenous Antioxidants: Some studies suggest that Grape Seed Extract may also enhance the activity of the body's own antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase.

Scientific Evidence
Numerous scientific studies have demonstrated the antioxidant capabilities of Grape Seed Extract:

- A study published in the *Journal of Agricultural and Food Chemistry* showed that Grape Seed Extract has a higher oxygen radical absorbance capacity (ORAC) value compared to other fruits and vegetables, indicating its superior antioxidant capacity.

- Research conducted on animals has shown that Grape Seed Extract can reduce oxidative stress and protect against tissue damage caused by free radicals.

- Clinical trials in humans have also indicated that supplementation with Grape Seed Extract can increase the total antioxidant capacity of the blood.

Benefits of Grape Seed Extract's Antioxidant Properties
The antioxidant properties of Grape Seed Extract offer a range of health benefits, including:

- Cardiovascular Health: By reducing oxidative stress, Grape Seed Extract may help lower the risk of heart disease and stroke.

- Cancer Prevention: The neutralization of free radicals can help prevent the initiation and progression of cancer.

- Skin Health: Topical application of Grape Seed Extract has been shown to protect skin from environmental damage and promote collagen synthesis, leading to healthier and more youthful-looking skin.

- Anti-Inflammatory Effects: The antioxidant properties of Grape Seed Extract may also contribute to its anti-inflammatory effects, which can be beneficial for conditions such as arthritis.

- Neuroprotection: The ability of Grape Seed Extract to cross the blood-brain barrier makes it a potential candidate for protecting the brain from oxidative stress associated with neurodegenerative diseases like Alzheimer's and Parkinson's.

In conclusion, the antioxidant properties of Grape Seed Extract are well-documented and offer a multitude of health benefits. Its high content of OPCs and its ability to combat oxidative stress make it a valuable addition to a health-conscious diet or supplement regimen.

5. Antioxidant Properties of Pine Bark Extract

5. Antioxidant Properties of Pine Bark Extract

Pine bark extract, also known as Pycnogenol, is derived from the bark of the French maritime pine tree (Pinus pinaster). This natural compound has been the subject of numerous scientific studies, many of which have focused on its antioxidant properties. The unique combination of bioflavonoids, particularly proanthocyanidins, found in pine bark extract is responsible for its potent antioxidant activity.

Mechanism of Antioxidant Action

The primary mechanism by which pine bark extract exerts its antioxidant effects is through the neutralization of free radicals. Free radicals are unstable molecules that can cause oxidative stress, leading to cellular damage and contributing to the aging process as well as the development of various diseases. Proanthocyanidins in pine bark extract are particularly effective at scavenging these harmful free radicals, thereby protecting cells from oxidative damage.

Bioavailability and Absorption

One of the advantages of pine bark extract is its high bioavailability, meaning that a significant portion of the ingested compound is absorbed by the body and can be utilized effectively. This is important for the antioxidant properties of the extract, as it ensures that the beneficial effects are realized within the body.

Skin Health Benefits

Pine bark extract's antioxidant properties have been linked to improved skin health. It is believed to help protect the skin from environmental stressors, such as UV radiation and pollution, which can lead to premature aging and skin damage. By neutralizing free radicals, pine bark extract may help reduce the appearance of fine lines, wrinkles, and age spots, as well as improve overall skin elasticity and hydration.

Cardiovascular Health

The antioxidant properties of pine bark extract have also been studied in relation to cardiovascular health. Research suggests that the extract may help improve blood flow, reduce inflammation, and lower blood pressure, all of which can contribute to a healthier heart. Additionally, the neutralization of free radicals may help protect the endothelial cells lining the blood vessels, which is crucial for maintaining vascular health.

Neuroprotective Effects

Pine bark extract's antioxidant capabilities extend to the nervous system, where it may provide neuroprotective effects. By reducing oxidative stress in the brain, pine bark extract could potentially help protect against neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as support cognitive function and memory.

In summary, the antioxidant properties of pine bark extract are multifaceted, offering a range of health benefits from skin protection to cardiovascular and neurological support. Its high bioavailability and effectiveness in neutralizing free radicals make it a valuable natural supplement for those seeking to enhance their antioxidant defense.

6. Health Benefits of Grape Seed Extract

6. Health Benefits of Grape Seed Extract

Grape Seed Extract is a powerful natural supplement that offers a multitude of health benefits due to its rich antioxidant content. Here are some of the key health benefits associated with Grape Seed Extract:

1. Heart Health: Grape Seed Extract is known to improve cardiovascular health by reducing the risk of heart disease. It helps to lower blood pressure, improve blood flow, and reduce the risk of blood clots.

2. Anti-Inflammatory Properties: The presence of proanthocyanidins in Grape Seed Extract has anti-inflammatory effects, which can help alleviate symptoms of various inflammatory conditions.

3. Cancer Prevention: The antioxidants in Grape Seed Extract may help neutralize free radicals that can damage cells and lead to cancer. Studies have shown that it may have a protective effect against certain types of cancer.

4. Skin Health: Grape Seed Extract is rich in polyphenols, which can help protect the skin from environmental damage, reduce the signs of aging, and improve skin elasticity.

5. Cholesterol Reduction: Grape Seed Extract has been shown to help lower LDL ("bad") cholesterol levels while increasing HDL ("good") cholesterol levels, contributing to overall heart health.

6. Blood Sugar Control: For individuals with diabetes or at risk of developing it, Grape Seed Extract can help regulate blood sugar levels, reducing the risk of complications.

7. Neurological Protection: The antioxidants in Grape Seed Extract may protect the brain from oxidative stress, potentially reducing the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's.

8. Immune System Support: By fighting off free radicals, Grape Seed Extract can support a healthy immune system, helping the body to resist infections and diseases.

9. Allergy Relief: Some studies suggest that Grape Seed Extract may help reduce the symptoms of allergies by stabilizing the release of histamines.

10. Eye Health: The antioxidants in Grape Seed Extract can protect the eyes from oxidative damage, potentially reducing the risk of age-related macular degeneration and cataracts.

11. Anti-Aging Effects: The overall antioxidant and anti-inflammatory properties of Grape Seed Extract contribute to its anti-aging effects, helping to maintain youthful skin and overall health.

12. Enhanced Athletic Performance: Grape Seed Extract has been found to improve blood flow and reduce muscle soreness, making it beneficial for athletes looking to enhance their performance and recovery.

Incorporating Grape Seed Extract into a daily health regimen can provide these benefits and more, supporting overall well-being and longevity. However, it's important to consult with a healthcare professional before starting any new supplement regimen, especially for individuals with pre-existing health conditions or those taking medications.

7. Health Benefits of Pine Bark Extract

7. Health Benefits of Pine Bark Extract

Pine bark extract, also known as Pycnogenol, is derived from the bark of the maritime pine tree and has been widely studied for its health-promoting properties. This section will delve into the various health benefits associated with pine bark extract, highlighting its potential role in improving overall well-being.

7.1. Cardiovascular Health
One of the most significant benefits of pine bark extract is its positive impact on cardiovascular health. Studies have shown that it can help improve blood flow, reduce blood pressure, and lower cholesterol levels. This is attributed to the extract's ability to strengthen blood vessel walls and enhance the elasticity of blood vessels, thereby reducing the risk of heart disease and stroke.

7.2. Anti-Inflammatory Properties
Pine bark extract has potent anti-inflammatory effects, making it a valuable natural remedy for various inflammatory conditions. It can help alleviate symptoms of arthritis, reduce swelling, and improve joint mobility. The extract's anti-inflammatory properties are also beneficial for skin health, as it can help reduce the appearance of wrinkles and age spots caused by inflammation.

7.3. Cognitive Function and Memory
Research suggests that pine bark extract may have neuroprotective effects, potentially improving cognitive function and memory. The extract's antioxidant properties can help protect brain cells from oxidative stress, which is known to contribute to cognitive decline and neurodegenerative diseases such as Alzheimer's.

7.4. Skin Health
Pine bark extract is rich in proanthocyanidins, which have been shown to improve skin health by promoting collagen production and reducing the breakdown of collagen fibers. This can result in improved skin elasticity, reduced appearance of fine lines and wrinkles, and a more youthful complexion.

7.5. Diabetes Management
Some studies have indicated that pine bark extract may help manage diabetes by improving insulin sensitivity and reducing blood sugar levels. This can be particularly beneficial for individuals with type 2 diabetes, as it may help prevent or manage complications associated with the condition.

7.6. Allergy Relief
Pine bark extract has been found to have antihistamine properties, which can help alleviate allergy symptoms such as sneezing, itching, and watery eyes. By reducing the release of histamine, an inflammatory compound involved in allergic reactions, pine bark extract may provide relief for those suffering from seasonal allergies or other types of hypersensitivity.

7.7. Enhanced Physical Performance
Athletes and individuals engaged in regular physical activity may benefit from pine bark extract's ability to improve blood flow and reduce inflammation. This can lead to enhanced physical performance, faster recovery times, and reduced muscle soreness after exercise.

7.8. Improved Vision
Pine bark extract's antioxidant properties may also support eye health and improve vision. Some studies have suggested that it can help reduce the risk of age-related macular degeneration and other vision-related disorders by protecting the retina from oxidative damage.

In conclusion, pine bark extract offers a wide range of health benefits, from cardiovascular support to improved cognitive function and skin health. Its potent antioxidant and anti-inflammatory properties make it a valuable addition to a healthy lifestyle. However, it is essential to consult with a healthcare professional before incorporating pine bark extract into your daily routine, especially if you have pre-existing health conditions or are taking medications.

8. Comparative Analysis of Antioxidant Strength

8. Comparative Analysis of Antioxidant Strength

When comparing the antioxidant strength of Grape Seed Extract and pine bark extract, it is essential to consider the types and concentrations of antioxidants present in each, as well as the overall effectiveness of these compounds in neutralizing free radicals and supporting overall health.

Grape Seed Extract:
Grape Seed Extract is rich in oligomeric proanthocyanidins (OPCs), which are known for their potent antioxidant activity. These compounds are particularly effective at scavenging free radicals and preventing oxidative stress. Studies have shown that Grape Seed Extract has a high ORAC (Oxygen Radical Absorbance Capacity) value, indicating its strong antioxidant capacity.

Pine Bark Extract:
Pine bark extract, specifically from the maritime pine bark, is a source of proanthocyanidins as well. However, it also contains other bioactive compounds such as taxifolin and catechins, which contribute to its antioxidant properties. Pine bark extract is known for its high content of bioflavonoids, which have been shown to have a synergistic effect with other antioxidants, enhancing their overall effectiveness.

Comparative Strength:
While both extracts are potent antioxidants, the comparative strength can vary based on the specific composition of the extracts and the methods used for extraction and standardization. Some studies suggest that Grape Seed Extract may have a higher ORAC value compared to pine bark extract, indicating a potentially greater antioxidant capacity. However, the presence of unique bioflavonoids in pine bark extract can also provide significant antioxidant benefits.

Synergistic Effects:
It's important to note that the antioxidant strength of these extracts is not solely determined by their individual components but also by how these components work together. The synergistic effects of the various antioxidants in grape seed and pine bark extracts can enhance their overall antioxidant capacity.

Clinical Evidence:
Clinical studies comparing the antioxidant strength of grape seed and pine bark extracts are limited. More research is needed to definitively determine which extract has a superior antioxidant profile. However, both extracts have been shown to provide significant health benefits when used appropriately.

In conclusion, while Grape Seed Extract may have a higher ORAC value, indicating a potentially greater antioxidant capacity, pine bark extract also offers unique benefits due to its diverse antioxidant profile. The choice between the two should be based on individual health needs and preferences, as both extracts can contribute to a comprehensive antioxidant strategy for maintaining good health.

9. Usage and Dosage Recommendations

9. Usage and Dosage Recommendations

When considering the use of Grape Seed Extract or pine bark extract for their health benefits, it's important to understand the recommended dosages and usage guidelines to ensure safety and effectiveness.

Grape Seed Extract Dosage Recommendations:
- The typical dosage for Grape Seed Extract ranges from 50 to 300 mg per day, depending on the product's concentration of oligomeric proanthocyanidins (OPCs).
- For general health maintenance, a lower dosage may be sufficient, while a higher dosage may be recommended for specific health conditions or under the guidance of a healthcare professional.
- It is crucial to follow the manufacturer's instructions and not to exceed the recommended dosage to avoid potential side effects.

Pine Bark Extract Dosage Recommendations:
- The standard dosage for pine bark extract, specifically Pycnogenol, is usually between 50 to 150 mg per day.
- The dosage can vary based on the individual's health goals and the condition being addressed.
- As with Grape Seed Extract, it is essential to adhere to the product's guidelines and consult a healthcare provider for personalized advice.

General Usage Tips:
- Both grape seed and pine bark extracts are available in various forms, including capsules, tablets, and powders. Choose a form that suits your preference and lifestyle.
- It is advisable to take these supplements with a meal to enhance absorption and reduce the risk of gastrointestinal upset.
- Keep the supplements out of reach of children and store them in a cool, dry place away from direct sunlight.

Precautions:
- Before starting any new supplement regimen, especially if you are pregnant, nursing, or have a pre-existing medical condition, consult with a healthcare professional.
- Be cautious when combining these supplements with medications, as they may interact with certain drugs, such as blood thinners or diabetes medications.
- Discontinue use and consult a healthcare provider if you experience any adverse reactions or side effects.

Monitoring and Adjustments:
- It may be necessary to adjust the dosage based on your body's response to the supplement.
- Regular check-ups with a healthcare provider can help monitor the effectiveness of the supplement and make any necessary adjustments to your regimen.

In conclusion, while both grape seed and pine bark extracts offer a range of health benefits, it is important to use them responsibly by following dosage recommendations and seeking professional advice when needed. This approach will help maximize their potential benefits while minimizing the risk of side effects.

10. Potential Side Effects and Precautions

10. Potential Side Effects and Precautions

While both Grape Seed Extract and pine bark extract have numerous health benefits, it is essential to be aware of potential side effects and precautions to ensure safe consumption. Here, we will discuss the possible risks associated with the use of these natural supplements.

Grape Seed Extract Side Effects:

1. Allergic Reactions: Some individuals may experience allergic reactions to Grape Seed Extract, including skin rashes, itching, and difficulty breathing.
2. Interaction with Medications: Grape Seed Extract can interact with blood thinners and other medications, leading to increased risk of bleeding or altered drug efficacy.
3. Pregnancy and Lactation: The safety of Grape Seed Extract during pregnancy and breastfeeding has not been well-established, so it is advised to avoid its use during these periods.
4. Kidney Issues: Excessive consumption of Grape Seed Extract may lead to kidney problems, particularly in individuals with pre-existing kidney conditions.

Pine Bark Extract Side Effects:

1. Gastrointestinal Distress: Some users may experience stomach upset, nausea, or diarrhea after taking pine bark extract.
2. Interaction with Medications: Like Grape Seed Extract, pine bark extract can interact with blood thinners and other medications, potentially leading to adverse effects.
3. Allergic Reactions: Individuals with allergies to pine trees or related species may experience allergic reactions to pine bark extract.
4. Pregnancy and Lactation: The safety of pine bark extract during pregnancy and breastfeeding is not well-documented, so caution is advised.

Precautions:

1. Consult a Healthcare Provider: Before starting any supplement regimen, it is crucial to consult with a healthcare provider, especially for individuals with pre-existing health conditions or those taking medications.
2. Follow Recommended Dosages: Adhering to the recommended dosages can help minimize the risk of side effects and ensure the effectiveness of the supplements.
3. Monitor for Side Effects: Users should be vigilant for any signs of adverse reactions and discontinue use if any occur, consulting a healthcare provider if necessary.
4. Quality and Purity: Ensure that the supplements are sourced from reputable manufacturers and are free from contaminants.

In conclusion, while Grape Seed Extract and pine bark extract offer numerous health benefits, it is essential to approach their use with caution and awareness of potential side effects. By following the recommended precautions and consulting with healthcare professionals, individuals can safely enjoy the benefits of these natural supplements.

11. Conclusion and Personal Recommendations

11. Conclusion and Personal Recommendations

After a thorough comparison of Grape Seed Extract and pine bark extract, it's clear that both these natural supplements offer a plethora of health benefits, primarily due to their rich antioxidant content. Both extracts have been studied for their potential to combat oxidative stress, inflammation, and support overall health.

Grape Seed Extract is particularly noted for its high concentration of oligomeric proanthocyanidins (OPCs), which are powerful antioxidants with a strong affinity for collagen, making them beneficial for skin health and potentially reducing the risk of cardiovascular diseases. Its anti-inflammatory and anti-allergic properties also make it a popular choice for those looking to improve their immune response and manage allergic reactions.

Pine Bark Extract, on the other hand, is rich in procyanidins and bioflavonoids, which are known for their ability to strengthen capillaries, veins, and arteries. It is often used to support healthy blood circulation and to reduce symptoms of chronic venous insufficiency. Additionally, its anti-inflammatory and antioxidant properties are beneficial for skin health and may contribute to improved cognitive function.

When comparing the antioxidant strength, both extracts have demonstrated significant free radical scavenging abilities, but the specific health conditions they are best suited for may vary. Grape Seed Extract may have an edge in skin and cardiovascular health, while pine bark extract could be more beneficial for vascular health and cognitive function.

In terms of usage and dosage, it's crucial to follow the recommended guidelines provided by the manufacturer or a healthcare professional. The optimal dosage can vary based on the individual's health condition, age, and other factors.

As with any supplement, potential side effects and precautions should be considered. While both grape seed and pine bark extracts are generally well-tolerated, they may interact with certain medications or exacerbate conditions in sensitive individuals. It's always advisable to consult with a healthcare provider before starting any new supplement regimen.

In conclusion, the choice between Grape Seed Extract and pine bark extract should be based on individual health goals and needs. If you're looking for a supplement to support skin health and cardiovascular wellness, Grape Seed Extract may be the better option. Conversely, if you're interested in improving vascular health and cognitive function, pine bark extract could be more suitable.

For personal recommendations, consider starting with a moderate dose of either supplement and monitor your body's response. It's also beneficial to incorporate a balanced diet rich in fruits, vegetables, and whole grains, which naturally contain antioxidants and other nutrients that support overall health.

Remember, supplements are meant to complement a healthy lifestyle, not replace it. Regular exercise, adequate sleep, and stress management are equally, if not more, important for maintaining good health. Always consult with a healthcare professional when making decisions about your health and wellness regimen.